ARG42216
anti-MTHFD1L antibody
anti-MTHFD1L antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MTHFD1L |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MTHFD1L |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 759-978 of Human MTHFD1L (NP_056255.2). |
| Conjugation | Un-conjugated |
| Alternate Names | MTC1THFS; dJ292B18.2; Formyltetrahydrofolate synthetase; EC 6.3.4.3; Monofunctional C1-tetrahydrofolate synthase, mitochondrial; FTHFSDC1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | A549 | ||||||
| Observed Size | ~ 117 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q3V3R1 Mouse Monofunctional C1-tetrahydrofolate synthase, mitochondrial Swiss-port # Q6UB35 Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial |
|---|---|
| Gene Symbol | MTHFD1L |
| Gene Full Name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
| Background | The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
| Function | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. [UniProt] |
| Cellular Localization | Mitochondrion. [UniProt] |
| Calculated MW | 106 kDa |
Images (1) Click the Picture to Zoom In
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ARG42216 anti-MTHFD1L antibody WB image
Western blot: 25 µg of A549 cell lysate stained with ARG42216 anti-MTHFD1L antibody at 1:1000 dilution.
