ARG66442
anti-MRGPRX1 / MRGX1 antibody
anti-MRGPRX1 / MRGX1 antibody for ICC/IF,Western blot and Human
Overview
Product Description | Rabbit Polyclonal antibody recognizes MRGPRX1 / MRGX1 |
---|---|
Tested Reactivity | Hu |
Tested Application | ICC/IF, WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | MRGPRX1 / MRGX1 |
Antigen Species | Human |
Immunogen | Synthetic peptide within aa. 240-320 of Human MRGX1. |
Conjugation | Un-conjugated |
Alternate Names | SNSR4; MRGX1; MGRG2; Sensory neuron-specific G-protein coupled receptor 3/4; GPCR; Mas-related G-protein coupled receptor member X1 |
Application Instructions
Application Suggestion |
|
||||||
---|---|---|---|---|---|---|---|
Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
Observed Size | ~ 36 kDa |
Properties
Form | Liquid |
---|---|
Purification | Affinity purification with immunogen. |
Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol and 0.5% BSA |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # Q96LB2 Human Mas-related G-protein coupled receptor member X1 |
---|---|
Gene Symbol | MRGPRX1 |
Gene Full Name | MAS-related GPR, member X1 |
Function | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner. [UniProt] |
Cellular Localization | Cell membrane; Multi-pass membrane protein. [UniProt] |
Calculated MW | 36 kDa |
Images (2) Click the Picture to Zoom In
-
ARG66442 anti-MRGPRX1 / MRGX1 antibody ICC/IF image
Immunofluorescence: HepG2 cells stained with ARG66442 anti-MRGPRX1 / MRGX1 antibody. The picture on the right is blocked with the synthetic peptide.
-
ARG66442 anti-MRGPRX1 / MRGX1 antibody WB image
Western blot: MCF7 cell lysate stained with ARG66442 anti-MRGPRX1 / MRGX1 antibody. The lane on the right is blocked with the synthetic peptide.