ARG66607

anti-MRC2 / Endo180 antibody

anti-MRC2 / Endo180 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes MRC2 / Endo180
Tested Reactivity Hu
Tested Application ICC/IF, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name MRC2 / Endo180
Antigen Species Human
Immunogen Synthetic peptide within aa. 90-170 of Human MRC2 / Endo180.
Conjugation Un-conjugated
Alternate Names CD280; CLEC13E; CD antigen CD280; UPAR-associated protein; Urokinase receptor-associated protein; Endocytic receptor 180; C-type lectin domain family 13 member E; Urokinase-type plasminogen activator receptor-associated protein; ENDO180; C-type mannose receptor 2; Macrophage mannose receptor 2; UPARAP

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:200 - 1:1000
IHC-P1:100 - 1:300
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol and 0.5% BSA
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 9902 Human MRC2

Swiss-port # Q9UBG0 Human C-type mannose receptor 2

Gene Symbol MRC2
Gene Full Name mannose receptor, C type 2
Background This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Function May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 167 kDa
PTM N-glycosylated. [UniProt]

Images (3) Click the Picture to Zoom In

  • ARG66607 anti-MRC2 / Endo180 antibody ICC/IF image

    Immunofluorescence: HepG2 cells stained with ARG66607 anti-MRC2 / Endo180 antibody. The picture on the right is blocked with the synthetic peptide.

  • ARG66607 anti-MRC2 / Endo180 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human brain tissue stained with ARG66607 anti-MRC2 / Endo180 antibody. The picture on the right is blocked with the synthetic peptide.

  • ARG66607 anti-MRC2 / Endo180 antibody WB image

    Western blot: 293 cell lysate stained with ARG66607 anti-MRC2 / Endo180 antibody at 1:1000 dilution.