ARG54285
anti-MPO / Myeloperoxidase antibody [MPO421-8B2] (PE)
anti-MPO / Myeloperoxidase antibody [MPO421-8B2] (PE) for Flow cytometry and Human
Inflammatory Cell Marker antibody; Neurophil Marker antibody
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [MPO421-8B2] recognizes MPO / Myeloperoxidase |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Specificity | The mouse monoclonal antibody MPO4218B2 recognizes human myeloperoxidase, a heme protein present in myeloblasts, neutrophils and monocytes. It is a marker of acute myelogenous leukemias and acute lymphoblastic leukemias. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MPO421-8B2 |
| Isotype | IgG1 |
| Target Name | MPO / Myeloperoxidase |
| Antigen Species | Human |
| Immunogen | Human myeloperoxidase |
| Conjugation | PE |
| Alternate Names | MPO; Myeloperoxidase; EC 1.11.2.2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| Buffer | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| Preservative | 15 mM Sodium azide |
| Stabilizer | 0.2% (w/v) high-grade protease free BSA |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MPO |
| Gene Full Name | myeloperoxidase |
| Background | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014] |
| Function | Myeloperoxidase (MPO): Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. [UniProt] |
| Highlight | Related products: MPO antibodies; MPO ELISA Kits; MPO Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: Exploring Antiviral Immune Response |
| Research Area | Inflammatory Cell Marker antibody; Neurophil Marker antibody |
| Calculated MW | 84 kDa |
Images (2) Click the Picture to Zoom In
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ARG54285 anti-MPO / Myeloperoxidase antibody [MPO421-8B2] (PE) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG54285 anti-MPO / Myeloperoxidase antibody [MPO421-8B2] (PE) (10 µl reagent / 100 µl of peripheral whole blood).
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ARG54285 anti-MPO / Myeloperoxidase antibody [MPO421-8B2] (PE) FACS image
Flow Cytometry: Separation of human neutrophil granulocytes (red-filled) from lymphocytes (black-dashed). Human peripheral whole blood stained with ARG54285 anti-MPO / Myeloperoxidase antibody [MPO421-8B2] (PE) (10 µl reagent / 100 µl of peripheral whole blood).
