ARG42605
anti-MOSC1 antibody
anti-MOSC1 antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MOSC1 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MOSC1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human MOSC1. |
| Conjugation | Un-conjugated |
| Alternate Names | Mitochondrial amidoxime-reducing component 1; EC 1.-.-.-; MOSC domain-containing protein 1; MOSC1; Molybdenum cofactor sulfurase C-terminal domain-containing protein 1; Moco sulfurase C-terminal domain-containing protein 1; mARC1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | NIH/3T3 | ||||
| Observed Size | ~ 37 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6NZQ8 Mouse E3 ubiquitin-protein ligase MARCH1 Swiss-port # Q9CW42 Mouse Mitochondrial amidoxime-reducing component 1 |
|---|---|
| Gene Symbol | MARC1 |
| Gene Full Name | mitochondrial amidoxime reducing component 1 |
| Function | Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045, PubMed:19053771). [UniProt] |
| Cellular Localization | Mitochondrion outer membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP. [UniProt] |
| Calculated MW | 37 kDa |
Images (1) Click the Picture to Zoom In
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ARG42605 anti-MOSC1 antibody WB image
Western blot: NIH/3T3 cell lysate stained with ARG42605 anti-MOSC1 antibody at 1:1000 diluiton, overnight at 4°C.
