ARG44544
anti-MMP20 antibody
anti-MMP20 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MMP20 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MMP20 |
| Antigen Species | Human |
| Immunogen | Human MMP20 synthesized peptide |
| Conjugation | Un-conjugated |
| Alternate Names | MMP20; Matrix Metallopeptidase 20 ; Matrix Metalloproteinase 20 (Enamelysin); Matrix Metalloproteinase-20; Enamel Metalloproteinase; Enamelysin; MMP-20; EC 3.4.24.22; EC 3.4.24.35; EC 3.4.24.-; EC 3.4.24; AI2A2 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 40% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MMP20 |
| Gene Full Name | Matrix Metallopeptidase 20 |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. |
| Function | Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. |
| Cellular Localization | Extracellular matrix, Secreted |
| Calculated MW | 54 kDa |
| PTM | Autocatalytic cleavage, Disulfide bond, Zymogen |
Images (2) Click the Picture to Zoom In
-
ARG44544 anti-MMP20 antibody WB image
Western blot: 823 stained with ARG44544 anti-MMP20 antibody.
-
ARG44544 anti-MMP20 antibody WB image
Western blot: Mouse brain stained with ARG44544 anti-MMP20 antibody.
