ARG44872
anti-MLH3 antibody
anti-MLH3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes MLH3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Target Name | MLH3 |
| Antigen Species | Human |
| Epitope | YEKQQAQGSG |
| Conjugation | Un-conjugated |
| Alternate Names | MLH3; MutL Homolog 3; DNA Mismatch Repair Protein Mlh3; MutL (E. Coli) Homolog 3; MutL Homolog 3 (E. Coli); MutL Protein Homolog 3; HNPCC7 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MLH3 |
| Gene Full Name | MutL Homolog 3 |
| Background | This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] |
| Function | Probably involved in the repair of mismatches in DNA. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG44872 anti-MLH3 antibody IHC-P image
Immunohistochemistry: Human endometrium stained with ARG44872 anti-MLH3 antibody at 10 µg/mL dilution.
