ARG44146
anti-MICALL2 antibody
anti-MICALL2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal recognizes MICALL2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MICALL2 |
| Antigen Species | Human |
| Immunogen | Human MICALL2 recombinant protein (Position: K132-Q741). |
| Conjugation | Un-conjugated |
| Alternate Names | MICALL2; MICAL Like; MICAL-L2; JRAB; Junctional Rab13-Binding Protein; Molecule Interacting With CasL-Like 2; MICAL-Like Protein 2; MGC46023; FLJ23471 |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MICALL2 |
| Gene Full Name | MICAL Like 2 |
| Background | Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; neuron projection; and recycling endosome. Predicted to colocalize with stress fiber. |
| Function | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth. |
| Cellular Localization | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endosome, Membrane, Tight junction |
| Calculated MW | 98 kDa |
| PTM | Phosphoprotein |
Images (3) Click the Picture to Zoom In
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ARG44146 anti-MICALL2 antibody IHC-P image
Immunohistochemistry: Human colorectal adenocarcinoma stained with ARG44146 anti-MICALL2 antibody at 2 μg/ml dilution.
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ARG44146 anti-MICALL2 antibody WB image
Western blot: U20S and K562 stained with ARG44146 anti-MICALL2 antibody at 0.5 μg/ml dilution.
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ARG44146 anti-MICALL2 antibody FACS image
Flow Cytometry: K562 stained with ARG44146 anti-MICALL2 antibody at 1 µg/10^6 cells dilution.
