ARG10201
anti-MCP3 antibody [113] (HRP)
anti-MCP3 antibody [113] (HRP) for ELISA and Human
Immune System antibody
Overview
| Product Description | HRP-conjugated Mouse Monoclonal antibody [113] recognizes Human MCP-3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | Does not show any cross reaction with other human cytokines or growth factors tested such as IL-1β, IL-8, MCAF, SAA and EGF. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 113 |
| Isotype | IgG1, kappa |
| Target Name | MCP3 |
| Antigen Species | Human |
| Immunogen | Recombinant human MCP-3 (M.W. 8.5kDa containing 76 amino acids residues) |
| Conjugation | HRP |
| Alternate Names | MCP3; NC28; Monocyte chemotactic protein 3; MARC; Small-inducible cytokine A7; FIC; C-C motif chemokine 7; Monocyte chemoattractant protein 3; MCP-3; SCYA7; SCYA6 |
Application Instructions
| Application Note | ELISA: In combination with capture antibody clone 542 (ARG10027), this HRP conjugated antibody can be used as tracer antibody for human MCP-3 detection in sandwich ELISA. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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Properties
| Form | Liquid |
|---|---|
| Purification | Protein G affinity purified |
| Buffer | 0.01M PBS (pH 7.2) and 50% Glycerol |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Keep the antibody in the dark and keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCL7 |
| Gene Full Name | chemokine (C-C motif) ligand 7 |
| Background | Macrophage/monocyte chemotactic protein-3 (MCP-3), like other two closely related chemokines (MCP1 and MCP-2), is chemotactic to monocytes, but not to neutrophils. MCP-3 showed 78% sequence homology with MCP-1 and 58% sequence homology with MCP-2. The primary receptor for MCP-3 is D6. MCP-3 also competes with MCP-1 to bind to CCR10, and competes with Rantes and MIP-1α to bind to CCR1. MCP-3 stimulates macrophage to secrete proteases. A variety of cancer cell lines express MCP-3, suggesting a role in tumor invasion and metastasia. |
| Function | Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. [UniProt] |
| Highlight | Related Antibody Duos and Panels: ARG30074 MCP3 ELISA Antibody Duo Related products: MCP3 antibodies; MCP3 ELISA Kits; MCP3 Duos / Panels; Anti-Mouse IgG secondary antibodies; |
| Research Area | Immune System antibody |
| Calculated MW | 11 kDa |
| PTM | O-glycosylated. |
