ARG44227
anti-MCCC2 antibody
anti-MCCC2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MCCC2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MCCC2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human MCCC2 |
| Conjugation | Un-conjugated |
| Protein Full Name | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial |
| Alternate Names | MCCC2; Methylcrotonyl-CoA Carboxylase Subuni 2; MCCB; 3-Methylcrotonyl-CoA Carboxylase Non-Biotin-Containing Subunit; Methylcrotonoyl-CoA Carboxylase Beta Chain, Mitochondrial; 3-Methylcrotonyl-CoA:Carbon Dioxide Ligase Subunit Beta; Methylcrotonoyl-Coenzyme A Carboxylase 2 (Beta); 3-Methylcrotonyl-CoA Carboxylase 2; MCCase Subunit Beta; EC 6.4.1.4; Non-Biotin Containing Subunit Of 3-Methylcrotonyl-CoA Carboxylase; 3-Methylcrotonyl-CoA Carboxylase Non-Biotin Containing Subunit; Methylcrotonoyl-CoA Carboxylase 2 (Beta); Methylcrotonoyl-CoA Carboxylase Beta; Testicular Secretory Protein Li 29; Methylcrotonoyl-CoA Carboxylase 2; Biotin Carboxylase; MCCCbeta; MCCCβ; MCCCB |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MCCC2 |
| Gene Full Name | Methylcrotonyl-Coa Carboxylase Subunit 2 |
| Background | This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Function | Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. |
| Cellular Localization | Mitochondrion |
| Calculated MW | 61 kDa |
| PTM | Acetylation |
Images (6) Click the Picture to Zoom In
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ARG44227 anti-MCCC2 antibody IHC-P image
Immunohistochemistry: Human breast cancer stained with ARG44227 anti-MCCC2 antibody at 2 μg/ml dilution.
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ARG44227 anti-MCCC2 antibody WB image
Western blot: HepG2 and RT4 stained with ARG44227 anti-MCCC2 antibody at 0.25 μg/mL dilution.
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ARG44227 anti-MCCC2 antibody IHC-P image
Immunohistochemistry: Rat kidney stained with ARG44227 anti-MCCC2 antibody at 2 μg/ml dilution.
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ARG44227 anti-MCCC2 antibody WB image
Western blot: Rat liver and Rat kidney stained with ARG44227 anti-MCCC2 antibody at 0.25 μg/mL dilution.
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ARG44227 anti-MCCC2 antibody IHC-P image
Immunohistochemistry: Mouse kidney stained with ARG44227 anti-MCCC2 antibody at 2 μg/ml dilution.
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ARG44227 anti-MCCC2 antibody WB image
Western blot: Mouse liver and Mouse kidney stained with ARG44227 anti-MCCC2 antibody at 0.25 μg/mL dilution.
