ARG44134
anti-MAEA antibody
anti-MAEA antibody for Flow cytometry,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal recognizes MAEA |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MAEA |
| Antigen Species | Human |
| Immunogen | Human MAEA recombinant protein (Position: M1-E349). |
| Conjugation | Un-conjugated |
| Alternate Names | MAEA; Macrophage Erythroblast Attacher, E3 Ubiquitin Ligase; P44EMLP; HLC-10; EMP; GID9; Cell Proliferation-Inducing Gene 5 Protein; E3 Ubiquitin-Protein Transferase MAEA; Human Lung Cancer Oncogene 10 Protein; Erythroblast Macrophage Protein; GID Complex Subunit 9, FYV10 Homolog (S. Cerevisiae); GID Complex Subunit 9, FYV10 Homolog; Macrophage Erythroblast Attacher; Lung Cancer-Related Protein 10; EC 2.3.2.27; EMLP; PIG5 |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MAEA |
| Gene Full Name | Macrophage Erythroblast Attacher, E3 Ubiquitin Ligase |
| Background | This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. |
| Function | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. |
| Cellular Localization | Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus |
| Calculated MW | 45 kDa |
| PTM | Phosphoprotein, Ubl conjugation |
Images (3) Click the Picture to Zoom In
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ARG44134 anti-MAEA antibody FACS image
Flow Cytometry: U251 stained with ARG44134 anti-MAEA antibody at 1 µg/10^6 cells dilution.
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ARG44134 anti-MAEA antibody WB image
Western blot: Rat brain and PC-12 stained with ARG44134 anti-MAEA antibody at 0.5 μg/ml dilution.
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ARG44134 anti-MAEA antibody WB image
Western blot: Mouse brain stained with ARG44134 anti-MAEA antibody at 0.5 μg/ml dilution.
