ARG41793
anti-MAD2L1BP / CMT2 antibody
anti-MAD2L1BP / CMT2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MAD2L1BP / CMT2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MAD2L1BP / CMT2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human MAD2L1BP / CMT2. |
| Conjugation | Un-conjugated |
| Alternate Names | MAD2L1-binding protein; Caught by MAD2 protein; CMT2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | A431 | ||||||||
| Observed Size | ~ 32 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MAD2L1BP |
| Gene Full Name | MAD2L1 binding protein |
| Background | The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| Function | May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle. [UniProt] |
| Calculated MW | 31 kDa |
Images (2) Click the Picture to Zoom In
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ARG41793 anti-MAD2L1BP / CMT2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue stained with ARG41793 anti-MAD2L1BP / CMT2 antibody.
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ARG41793 anti-MAD2L1BP / CMT2 antibody WB image
Western blot: A431 cell lysate stained with ARG41793 anti-MAD2L1BP / CMT2 antibody.
