ARG42646
anti-LTBR / Lymphotoxin beta Receptor antibody
anti-LTBR / Lymphotoxin beta Receptor antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LTBR / Lymphotoxin beta Receptor |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | LTBR / Lymphotoxin beta Receptor |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 420-435 of Human LTBR / Lymphotoxin beta Receptor (ATPSNRGPRNQFITHD). |
| Conjugation | Un-conjugated |
| Alternate Names | TNF-RIII; LT-BETA-R; Tumor necrosis factor receptor superfamily member 3; TNF-R-III; TNFR-III; TNFR-RP; TNFR3; D12S370; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; TNFCR; Tumor necrosis factor receptor type III; Lymphotoxin-beta receptor; TNFR2-RP; CD18; TNFRSF3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HeLa and A549 | ||||||
| Observed Size | ~ 58 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide, 0.05% Thimerosal and 5% BSA. |
| Preservative | 0.05% Sodium azide and 0.05% Thimerosal |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P36941 Human Tumor necrosis factor receptor superfamily member 3 |
|---|---|
| Gene Symbol | LTBR |
| Gene Full Name | lymphotoxin beta receptor (TNFR superfamily, member 3) |
| Background | This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012] |
| Function | Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 47 kDa |
Images (2) Click the Picture to Zoom In
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ARG42646 anti-LTBR / Lymphotoxin beta Receptor antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human intestinal cancer tissue stained with ARG42646 anti-LTBR / Lymphotoxin beta Receptor antibody.
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ARG42646 anti-LTBR / Lymphotoxin beta Receptor antibody WB image
Western blot: 40 µg of HeLa and A549 whole cell lysates stained with ARG42646 anti-LTBR / Lymphotoxin beta Receptor antibody at 0.5 µg/ml dilution.
