ARG45369
anti-LTBP1 antibody [5L38]
anti-LTBP1 antibody [5L38] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [5L38] recognizes LTBP1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 5L38 |
| Isotype | IgG1 |
| Target Name | LTBP1 |
| Antigen Species | Human |
| Immunogen | Recombinant Human LTBP1. |
| Conjugation | Un-conjugated |
| Alternate Names | LTBP1; Latent Transforming Growth Factor Beta Binding Protein 1; Transforming Growth Factor Beta-1-Binding Protein 1; TGF-Beta1-BP-1; Latent-Transforming Growth Factor Beta-Binding Protein 1; LTBP-1; ARCL2E |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Powder |
|---|---|
| Purification | Protein G chromatography |
| Buffer | PBS |
| Reconstitution | PBS |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q14766 Human Latent-transforming growth factor beta-binding protein 1 |
|---|---|
| Gene Symbol | LTBP1 |
| Gene Full Name | Latent Transforming Growth Factor Beta Binding Protein 1 |
| Background | The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space |
| Cellular Localization | Extracellular matrix; Secreted. [UniProt] |
| Calculated MW | 187 kDa |
| PTM | Disulfide bond; Glycoprotein; Hydroxylation; Phosphoprotein. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG45369 anti-LTBP1 antibody [5L38] IHC-P image
Immunohistochemistry: Human placental stained with ARG45369 anti-LTBP1 antibody [5L38].
