ARG43766
anti-LRRK2 phospho (Ser395) antibody
anti-LRRK2 phospho (Ser395) antibody for ICC/IF,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LRRK2 phospho (Ser395) |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | LRRK2 |
| Antigen Species | Human |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding Ser395 of human LRRK2. |
| Conjugation | Un-conjugated |
| Protein Full Name | Leucine-rich repeat serine/threonine-protein kinase 2 |
| Alternate Names | PARK8; RIPK7; ROCO2; AURA17; DARDARIN; Leucine-rich repeat serine/threonine-protein kinase 2; Parkinson Disease (Autosomal Dominant) 8; Augmented In Rheumatoid Arthritis 17 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.05% BSA, 40% Glycerol and 0.01% Sodium azide. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 0.05% BSA and 40% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q5S006 Mouse Leucine-rich repeat serine/threonine-protein kinase 2 Swiss-port # Q5S007 Human Leucine-rich repeat serine/threonine-protein kinase 2 |
|---|---|
| Gene Symbol | LRRK2 |
| Gene Full Name | leucine rich repeat kinase 2 |
| Background | This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] |
| Function | LRRK2 (Leucine Rich Repeat Kinase 2) is a Protein Coding gene. Diseases associated with LRRK2 include Parkinson Disease 8, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Signaling by PTK6 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is BRAF. [GeneCard] |
| Cellular Localization | Cell projection; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome; Golgi apparatus; Lysosome; Membrane; Mitochondrion; Mitochondrion outer membrane; Synapse |
| Calculated MW | 286 kDa |
| PTM | Phosphoprotein |
