ARG43838
anti-LIAS antibody
anti-LIAS antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LIAS. |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Lipoic Acid Synthetase |
| Immunogen | Synthetic peptide from human LIAS. |
| Conjugation | Un-conjugated |
| Protein Full Name | Lipoyl synthase, mitochondrial |
| Alternate Names | LIAS; Lipoic Acid Synthetase; LAS; Lipoyl Synthase, Mitochondrial; Lipoate Synthase; EC 2.8.1.8; Lip-Syn; LS; Lipoic Acid Synthase; HUSSY-01; HGCLAS; PDHLD; LIP1 |
Application Instructions
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography |
| Buffer | PBS (pH 7.4) with 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | LIAS |
| Gene Full Name | Lipoic Acid Synthetase |
| Background | The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy. Alternative splicing occurs at this locus, and several transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Aug 2020] |
| Function | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. |
| Cellular Localization | Mitochondrion |
Images (4) Click the Picture to Zoom In
-
ARG43838 anti-LIAS antibody IHC-P image
Immunohistochemistry: Human gastric cancer stained with ARG43838 anti-LIAS antibody.
-
ARG43838 anti-LIAS antibody ICC/IF image
Immunofluorescence: Hela cells stained with ARG43838 anti-LIAS antibody.
-
ARG43838 anti-LIAS antibody IHC-P image
Immunohistochemistry: Rat muscle stained with ARG43838 anti-LIAS antibody.
-
ARG43838 anti-LIAS antibody WB imgage
Western blot: MCF7 cell stained with ARG43838 anti-LIAS antibody.
