ARG44396
anti-L3MBTL2 antibody
anti-L3MBTL2 antibody for IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes L3MBTL2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | L3MBTL2 |
| Antigen Species | Human |
| Immunogen | Human L3MBTL2 recombinant protein (aa. sequence: E208-Q701). |
| Conjugation | Un-conjugated |
| Alternate Names | L3MBTL2; L3MBTL Histone Methyl-Lysine Binding Protein 2; L3MBTL2, Polycomb Repressive Complex 1 Subunit; Lethal(3)Malignant Brain Tumor-Like Protein 2; H-L(3)Mbt-Like Protein 2; L(3)Mbt-Like Protein 2 |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links |
Swiss-port # Q969R5 Human Lethal(3)malignant brain tumor-like protein 2 |
|---|---|
| Gene Symbol | L3MBTL2 |
| Gene Full Name | L3MBTL Histone Methyl-Lysine Binding Protein 2 |
| Background | Enables methylated histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Located in nucleus. |
| Function | Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. |
| Cellular Localization | Nucleus |
| Calculated MW | 79 kDa |
| PTM | Isopeptide bond, Phosphoprotein, Ubl conjugation |
Images (4) Click the Picture to Zoom In
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ARG44396 anti-L3MBTL2 antibody IHC-P image
Immunohistochemistry: Human colorectal adenocarcinoma stained with ARG44396 anti-L3MBTL2 antibody at 2 μg/mL dilution.
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ARG44396 anti-L3MBTL2 antibody ICC/IF image
Immunofluorescence: U2OS stained with ARG44396 anti-L3MBTL2 antibody at 5 μg/mL dilution.
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ARG44396 anti-L3MBTL2 antibody WB image
Western blot: 293T andn HeLa stained with ARG44396 anti-L3MBTL2 antibody at 0.5 μg/mL dilution.
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ARG44396 anti-L3MBTL2 antibody IHC-P image
Immunohistochemistry: Human esophageal squamous carcinoma stained with ARG44396 anti-L3MBTL2 antibody at 2 μg/mL dilution.
