ARG43462
anti-KMT3C / SMYD2 antibody
anti-KMT3C / SMYD2 antibody for ICC/IF,Western blot and Human,Mouse
Overview
Product Description | Rabbit Polyclonal antibody recognizes KMT3C / SMYD2. |
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Tested Reactivity | Hu, Ms |
Tested Application | ICC/IF, WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | KMT3C / SMYD2 |
Antigen Species | Human |
Immunogen | Purified recombinant protein corresponding to human KMT3C / SMYD2. |
Conjugation | Un-conjugated |
Protein Full Name | N-lysine methyltransferase SMYD2 |
Alternate Names | KMT3C; HSKM-B; ZMYND14 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | SMYD2 |
Gene Full Name | SET and MYND domain containing 2 |
Background | SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008] |
Function | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. [UniProt] |
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