ARG64368
anti-KMT3A / SETD2 antibody
anti-KMT3A / SETD2 antibody for Flow cytometry and Human
Gene Regulation antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes KMT3A / SETD2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Dog, Pig |
| Tested Application | FACS |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KMT3A / SETD2 |
| Antigen Species | Human |
| Immunogen | C-ERDPDKQTQNKE |
| Conjugation | Un-conjugated |
| Alternate Names | HIF-1; SET domain-containing protein 2; SET2; Huntingtin-interacting protein B; Huntingtin yeast partner B; KMT3A; Huntingtin-interacting protein 1; hSET2; EC 2.1.1.43; HBP231; Lysine N-methyltransferase 3A; HIP-1; p231HBP; HSPC069; Histone-lysine N-methyltransferase SETD2; HYPB |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9BYW2 Human Histone-lysine N-methyltransferase SETD2 |
|---|---|
| Background | Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008] |
| Research Area | Gene Regulation antibody |
| Calculated MW | 288 kDa |
| PTM | May be automethylated. |
Images (1) Click the Picture to Zoom In
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ARG64368 anti-KMT3A / SETD2 antibody FACS image
Flow Cytometry: Paraformaldehyde-fixed HepG2 cells permeabilized with 0.5% Triton. Cells were stained with ARG64368 anti-KMT3A / SETD2 antibody (blue line) at 10 µg/ml dilution and overnight, followed by incubation with Alexa FluorR 488 labelled secondary antibody. IgG control: Unimmunized goat IgG (black line).
