ARG21032
anti-KLRG1 antibody [2F1]
anti-KLRG1 antibody [2F1] for Flow cytometry,Immunoprecipitation,Western blot and Human,Mouse
Overview
| Product Description | Syrian Hamster Monoclonal antibody [2F1] recognizes KLRG1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | FACS, IP, WB |
| Specificity | The clone 2F1 reacts with mouse killer cell lectin-like receptor G1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). |
| Host | Syrian Hamster |
| Clonality | Monoclonal |
| Clone | 2F1 |
| Isotype | IgG2 |
| Target Name | KLRG1 |
| Antigen Species | Mouse |
| Immunogen | IL-2-activated NK cells (A-LAK cells) from B6 (H-2b) mice |
| Conjugation | Un-conjugated |
| Alternate Names | 2F1; MAFA-L; C-type lectin domain family 15 member A; MAFA-2F1; MAFA-like receptor; CLEC15A; Killer cell lectin-like receptor subfamily G member 1; MAFA; ITIM-containing receptor MAFA-L; Mast cell function-associated antigen; MAFA-LIKE |
Application Instructions
| Application Suggestion |
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| Application Note | WB: Under non-reducing condition. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | BBS (pH 8.2) |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O88713 Mouse Killer cell lectin-like receptor subfamily G member 1 Swiss-port # Q96E93 Human Killer cell lectin-like receptor subfamily G member 1 |
|---|---|
| Gene Symbol | KLRG1 |
| Gene Full Name | killer cell lectin-like receptor subfamily G, member 1 |
| Background | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008] |
| Function | Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. [UniProt] |
| Calculated MW | 22 kDa |
