ARG54623
anti-KLK4 antibody
anti-KLK4 antibody for Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KLK4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Specificity | This antibody recognizes the geneproduct hk4 of human KLK4 (alsoknown as KLK-L1), one of the manykallikrein serine proteases associatedwith carcinogenesis. KLK4 is upregulatedby androgens and progestinsand has been associated with prostateand breast cancers and possibly withother cancers. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KLK4 |
| Antigen Species | Human |
| Immunogen | Peptide corresponding to aa242-254 of human KLK4 protein |
| Conjugation | Un-conjugated |
| Alternate Names | PSTS; Enamel matrix serine proteinase 1; Kallikrein-like protein 1; EMSP; PRSS17; ARM1; Serine protease 17; KLK-L1; Kallikrein-4; EC 3.4.21.-; Prostase; EMSP1; AI2A1; kallikrein |
Application Instructions
| Application Note | Western blot: use at 1:500 - 1:1,000 dilution. A band of approximately 39 kD is detected. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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Properties
| Form | Liquid |
|---|---|
| Purification | affinity-purified antibody |
| Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KLK4 |
| Gene Full Name | kallikrein-related peptidase 4 |
| Background | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014] |
| Function | Involved in enamel formation. [UniProt] |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody |
| Calculated MW | 27 kDa |
| PTM | N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues. |
