ARG45663
anti-KLK11 antibody
anti-KLK11 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KLK11 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KLK11 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to C-terminal region of human KLK11. |
| Conjugation | Un-conjugated |
| Alternate Names | KLK11; kallikrein-related peptidase 11; Trypsin-like protease; Kallikrein-11; hK11; PRSS20; EC 3.4.21.-; Serine protease 20; TLSP; Hippostasin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 31 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Thimerosal and 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KLK11 |
| Gene Full Name | kallikrein-related peptidase 11 |
| Background | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009] |
| Function | Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. [UniProt] |
| Cellular Localization | Golgi apparatus; Secreted. [UniProt] |
| Calculated MW | 31 kDa |
| PTM | Disulfide bond; Glycoprotein; Zymogen. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG45663 anti-KLK11 antibody IHC-P image
Immunohistochemistry: Human prostatic cancer stained with ARG45663 anti-KLK11 antibody.
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ARG45663 anti-KLK11 antibody WB image
Western blot: U87 stained with ARG45663 anti-KLK11 antibody.
