ARG45637
anti-KLK1 / Kallikrein 1 antibody
anti-KLK1 / Kallikrein 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KLK1 / Kallikrein 1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KLK1 / Kallikrein 1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to middle region of human KLK1 / Kallikrein 1. |
| Conjugation | Un-conjugated |
| Alternate Names | KLK1; Kallikrein 1; Klk6; Kidney/Pancreas/Salivary Gland Kallikrein; Kallikrein 1, Renal/Pancreas/Salivary; Tissue Kallikrein; Kallikrein-1; EC 3.4.21.35 47; Kallikrein Serine Protease 1; Glandular Kallikrein 1; EC 3.4.21 47; KLKR; HK1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 29 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Thimerosal and 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KLK1 |
| Gene Full Name | Kallikrein 1 |
| Background | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008 |
| Function | Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. ( KLK1_HUMAN,P06870 ) (Microbial infection) Cleaves Neisseria meningitidis NHBA in saliva; Neisseria is an obligate commensal of the nasopharyngeal mucosa. [UniProt] |
| Cellular Localization | extracellular exosome. [UniProt] |
| Calculated MW | 29 kDa |
| PTM | Disulfide bond; Glycoprotein; Zymogen. [UniProt] |
Images (4) Click the Picture to Zoom In
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ARG45637 anti-KLK1 / Kallikrein 1 antibody IHC-P image
Immunohistochemistry: Human pancreatic cancer stained with ARG45637 anti-KLK1 / Kallikrein 1 antibody at 2 μg/ml dilution.
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ARG45637 anti-KLK1 / Kallikrein 1 antibody WB image
Western blot: Rat pancreas stained with ARG45637 anti-KLK1 / Kallikrein 1 antibody at 0.5 μg/ml dilution.
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ARG45637 anti-KLK1 / Kallikrein 1 antibody WB image
Western blot: Mouse pancreas stained with ARG45637 anti-KLK1 / Kallikrein 1 antibody at 0.5 μg/ml dilution.
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ARG45637 anti-KLK1 / Kallikrein 1 antibody WB image
Western blot: KLK1 / Kallikrein 1 recombinant protein stained with ARG45637 anti-KLK1 / Kallikrein 1 antibody at 0.5 μg/ml dilution.
