ARG45244
anti-KLF10 antibody
anti-KLF10 antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Polyclonal antibody recognizes KLF10 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KLF10 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human KLF10. |
| Conjugation | Un-conjugated |
| Alternate Names | KLF10; KLF Transcription Factor 10; TIEG1; EGRA; TIEG; Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1; TGFB-Inducible Early Growth Response Protein 1; Krueppel-Like Factor 10; Kruppel Like Factor 10; EGR-Alpha; Zinc Finger Transcription Factor TIEG; TGFB Inducible Early Growth Response; Early Growth Response Alpha; Early Growth Response-Alpha; TIEG-1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 55 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KLF10 |
| Gene Full Name | KLF Transcription Factor 10 |
| Background | This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 53 kDa |
| PTM | Phosphoprotein ; Ubl conjugation. [UniProt] |
