ARG45569
anti-KISS1R / GRP54 antibody
anti-KISS1R / GRP54 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KISS1R / GRP54 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KISS1R / GRP54 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human KISS1R / GRP54. |
| Conjugation | Un-conjugated |
| Alternate Names | KISS1R; KISS1 receptor; G-protein coupled receptor 54; Metastin receptor; Kisspeptins receptor; HOT7T175; HH8; CPPB1; AXOR12; Hypogonadotropin-1; KiSS-1 receptor; hOT7T175; KISS-1R; GPR54; G-protein coupled receptor OT7T175; KiSS-1R |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 80 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KISS1R |
| Gene Full Name | KISS1 receptor |
| Background | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008] |
| Function | Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. [UniProt] |
| Cellular Localization | Cell membrane; Multi-pass membrane protein.. [UniProt] |
| Calculated MW | 43 kDa |
| PTM | Disulfide bond ; Glycoprotein. [UniProt] |
Images (7) Click the Picture to Zoom In
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ARG45569 anti-KISS1R / GRP54 antibody IHC-P image
Immunohistochemistry: Human gall bladder adenosquamous carcinoma stained with ARG45569 anti-KISS1R / GRP54 antibody at 2 μg/ml dilution.
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ARG45569 anti-KISS1R / GRP54 antibody ICC/IF image
Immunofluorescence: CACO-2 stained with ARG45569 anti-KISS1R / GRP54 antibody at 5 μg/ml dilution.
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ARG45569 anti-KISS1R / GRP54 antibody WB image
Western blot: MCF-7 stained with ARG45569 anti-KISS1R / GRP54 antibody at 0.5 μg/ml dilution.
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ARG45569 anti-KISS1R / GRP54 antibody WB image
Western blot: Rat kidney stained with ARG45569 anti-KISS1R / GRP54 antibody at 0.5 μg/ml dilution.
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ARG45569 anti-KISS1R / GRP54 antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG45569 anti-KISS1R / GRP54 antibody at 2 μg/ml dilution.
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ARG45569 anti-KISS1R / GRP54 antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG45569 anti-KISS1R / GRP54 antibody at 2 μg/ml dilution.
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ARG45569 anti-KISS1R / GRP54 antibody WB image
Western blot: Mouse kidney stained with ARG45569 anti-KISS1R / GRP54 antibody at 0.5 μg/ml dilution.
