ARG44344
anti-KIR3DS1 / CD158e2 antibody
anti-KIR3DS1 / CD158e2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KIR3DS1 / CD158e2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KIR3DS1 / CD158e2 |
| Antigen Species | Human |
| Immunogen | Human KIR3DS1 / CD158e2 recombinant fusion protein (a.a. sequence: 80-340). |
| Conjugation | Un-conjugated |
| Alternate Names | KIR3DS1; Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Short Cytoplasmic Tail 1; Killer Cell Immunoglobulin-Like Receptor, Three Domains, Short Cytoplasmic Tail, 1; Killer Cell Immunoglobulin-Like Receptor 3DS1; Natural Killer-Associated Transcript 10; NKAT-10; Nkat10; Killer Cell Immunoglobulin-Like Receptor KIR3DS1; KIR-123FM; CD158E2; KIR-G1; NKAT10 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS, 0.02% sodium azide and 50% Glycerol. |
| Preservative | 0.02% sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q14943 Human Killer cell immunoglobulin-like receptor 3DS1 |
|---|---|
| Gene Symbol | KIR3DS1 |
| Gene Full Name | Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Short Cytoplasmic Tail 1 |
| Background | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Function | Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production. |
| Cellular Localization | Cell membrane, Membrane |
| Calculated MW | 42 kDa |
| PTM | Disulfide bond, Glycoprotein |
Images (5) Click the Picture to Zoom In
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ARG44344 anti-KIR3DS1 / CD158e2 antibody IHC-P image
Immunohistochemistry: Human liver stained with ARG44344 anti-KIR3DS1 / CD158e2 antibody at 1:100 dilution.
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ARG44344 anti-KIR3DS1 / CD158e2 antibody WB image
Western blot: Jururkat, A549 and THP-1 stained with ARG44344 anti-KIR3DS1 / CD158e2 antibody at 1:1000 dilution.
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ARG44344 anti-KIR3DS1 / CD158e2 antibody WB image
Western blot: Rat liver stained with ARG44344 anti-KIR3DS1 / CD158e2 antibody at 1:1000 dilution.
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ARG44344 anti-KIR3DS1 / CD158e2 antibody WB image
Western blot: Mouse liver, Mouse kidney and Mouse pancreas stained with ARG44344 anti-KIR3DS1 / CD158e2 antibody at 1:1000 dilution.
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ARG44344 anti-KIR3DS1 / CD158e2 antibody IHC-P image
Immunohistochemistry: Human mammary cancer stained with ARG44344 anti-KIR3DS1 / CD158e2 antibody at 1:100 dilution.
