ARG56918
anti-KIR2DS4 antibody [5F2]
anti-KIR2DS4 antibody [5F2] for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [5F2] recognizes KIR2DS4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 5F2 |
| Isotype | IgG2b, kappa |
| Target Name | KIR2DS4 |
| Antigen Species | Human |
| Immunogen | Recombinant fragment of Human KIR2DS4. |
| Conjugation | Un-conjugated |
| Alternate Names | Natural killer-associated transcript 8; KKA3; NKAT8; KIR1D; NKAT-8; MHC class I NK cell receptor; p58 NK receptor CL-39/CL-17; P58 natural killer cell receptor clones CL-39/CL-17; CD158I; KIR412; KIR2DS1; CD158 antigen-like family member I; Killer cell immunoglobulin-like receptor 2DS4; CD antigen CD158i |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 10% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P43632 Human Killer cell immunoglobulin-like receptor 2DS4 |
|---|---|
| Gene Symbol | KIR2DS4 |
| Gene Full Name | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 |
| Background | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| Function | Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. [UniProt] |
| Calculated MW | 34 kDa |
Images (1) Click the Picture to Zoom In
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ARG56918 anti-KIR2DS4 antibody [5F2] WB image
Western blot: 100 ng of 1) KIR2DL1, 2) KIR2DL3, 3) KIR2DL4, and 4) KIR2DS4 Recombinant proteins stained with ARG56918 anti-KIR2DS4 antibody [5F2] at 1:1000. Arrow indicates recombinant Human KIR2DS4 protein.
