ARG64570
anti-KCNQ4 antibody
anti-KCNQ4 antibody for Western blot and Human
Neuroscience antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes KCNQ4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_004691.2; NP_751895.1); may cross-react in Mouse; |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KCNQ4 |
| Antigen Species | Human |
| Immunogen | C-DKGPSDAEVVDE |
| Conjugation | Un-conjugated |
| Alternate Names | DFNA2; Voltage-gated potassium channel subunit Kv7.4; KQT-like 4; DFNA2A; Potassium voltage-gated channel subfamily KQT member 4; KV7.4; Potassium channel subunit alpha KvLQT4 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P56696 Human Potassium voltage-gated channel subfamily KQT member 4 |
|---|---|
| Background | The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Research Area | Neuroscience antibody |
| Calculated MW | 77 kDa |
Images (1) Click the Picture to Zoom In
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ARG64570 anti-KCNQ4 antibody WB image
Western Blot: Cerebellum lysate (35 µg protein in RIPA buffer) stained with ARG64570 anti-KCNQ4 antibody at 2 µg/ml dilution.
