ARG66452
anti-KCNC4 / Kv3.4 antibody
anti-KCNC4 / Kv3.4 antibody for Western blot and Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KCNC4 / Kv3.4 |
|---|---|
| Tested Reactivity | Rat |
| Predict Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KCNC4 / Kv3.4 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide within the N-terminal region of Human KCNC4 / Kv3.4. |
| Conjugation | Un-conjugated |
| Alternate Names | C1orf30; KSHIIIC; Potassium voltage-gated channel subfamily C member 4; HKSHIIIC; Voltage-gated potassium channel subunit Kv3.4; KV3.4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 30% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q63734 Rat Potassium voltage-gated channel subfamily C member 4 |
|---|---|
| Gene Symbol | KCNC4 |
| Gene Full Name | potassium channel, voltage gated Shaw related subfamily C, member 4 |
| Background | The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] |
| Function | This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. [UniProt] |
| Cellular Localization | Membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 70 kDa |
| PTM | Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG66452 anti-KCNC4 / Kv3.4 antibody WB image
Western blot: Rat brain whole cell lysate stained with ARG66452 anti-KCNC4 / Kv3.4 antibody.
