ARG58716
anti-KAT2A / GCN5 antibody
anti-KAT2A / GCN5 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KAT2A / GCN5 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KAT2A / GCN5 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-100 of Human KAT2A (NP_066564.2). |
| Conjugation | Un-conjugated |
| Alternate Names | EC 2.3.1.48; HsGCN5; Histone acetyltransferase KAT2A; GCN5L2; hGCN5; PCAF-b; GCN5; General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; Lysine acetyltransferase 2A; STAF97 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | MCF7 | ||||||||
| Observed Size | 94 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KAT2A |
| Gene Full Name | K(lysine) acetyltransferase 2A |
| Background | KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] |
| Function | Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 94 kDa |
Images (2) Click the Picture to Zoom In
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ARG58716 anti-KAT2A / GCN5 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat kidney stained with ARG58716 anti-KAT2A / GCN5 antibody at 1:100 dilution.
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ARG58716 anti-KAT2A / GCN5 antibody WB image
Western blot: 25 µg of MCF7 cell lysate stained with ARG58716 anti-KAT2A / GCN5 antibody.
