ARG63322
anti-JIP3 / Syd 2 / JSAP1 antibody
anti-JIP3 / Syd 2 / JSAP1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Mouse
Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes JIP3 / Syd 2 / JSAP1 |
|---|---|
| Tested Reactivity | Ms |
| Predict Reactivity | Hu, Rat, Cow |
| Tested Application | IHC-P |
| Specificity | This antibody is expected to recognise both reported Human isoforms of this protein (as represented by NP_055948.2 and NP_001035529.1). |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | JIP3 / Syd 2 / JSAP1 |
| Antigen Species | Human |
| Immunogen | MEIQMDEGGGVV-C |
| Conjugation | Un-conjugated |
| Alternate Names | JIP-3; Mitogen-activated protein kinase 8-interacting protein 3; syd; JIP3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JSAP1; C-Jun-amino-terminal kinase-interacting protein 3; SYD2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9ESN9 Mouse C-Jun-amino-terminal kinase-interacting protein 3 |
|---|---|
| Background | The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
| Research Area | Signaling Transduction antibody |
| Calculated MW | 147 kDa |
| PTM | Phosphorylation by ROCK1 is crucial for the recruitment of JNK. |
Images (1) Click the Picture to Zoom In
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ARG63322 anti-JIP3 / Syd 2 / JSAP1 antibody IHC-P image
Immunohistochemistry: Paraffin embedded Mouse Brain. (Steamed antigen retrieval with citrate buffer pH 6) stained with ARG63322 anti-JIP3 / Syd 2 / JSAP1 antibody at 4 µg/ml dilution followed by HRP-staining.
