ARG45016
anti-IgG1 antibody [RM117]
anti-IgG1 antibody [RM117] for ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Monoclonal antibody [RM117] recognizes IgG1. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, ICC/IF, IHC-P |
| Specificity | This antibody reacts to the heavy chain of human IgG1. RM117 does not cross react to any other IgG subclasses (IgG2, IgG3, or IgG4), and shows no cross reactivity to IgM, IgA, IgD, IgE. RM117 does not react to monkey (Cyno or Rhesus) IgG, mouse IgG, rat IgG, or goat IgG. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | RM117 |
| Isotype | IgG |
| Target Name | IgG1 |
| Antigen Species | Human |
| Immunogen | Peptide corresponding to the hinge region of Human IgG1 |
| Target Ig | IgG1 |
| Conjugation | Un-conjugated |
| Alternate Names | IGHG1; Immunoglobulin Heavy Constant Gamma 1 (G1m Marker); Constant Region Of Heavy Chain Of IgG1; Immunoglobulin Heavy Constant Gamma 1; Immunoglobulin Gamma 1 (Gm Marker); Ig Gamma-1 Chain C Region KOL; Ig Gamma-1 Chain C Region NIE; Ig Gamma-1 Chain C Region EU; Ig Gamma-1 Chain C Region |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Buffer | PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide |
|---|---|
| Preservative | 0.09% sodium azide |
| Stabilizer | 50% Glycerol, 1% BSA and 0.09% |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IGHG1 |
| Gene Full Name | Immunoglobulin Heavy Constant Gamma 1 (G1m Marker) |
| Background | Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to act upstream of or within several processes, including immunoglobulin mediated immune response; positive regulation of hypersensitivity; and positive regulation of phagocytosis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] |
| Function | The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. [Uniprot] |
| Cellular Localization | Cell membrane, Immunoglobulin, Membrane, Secreted. [Uniprot] |
| PTM | Disulfide bond, Glycoprotein. [Uniprot] |
