ARG62518
anti-IgD antibody [IgD26]
anti-IgD antibody [IgD26] for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
Developmental Biology antibody; Immune System antibody
Overview
| Product Description | Mouse Monoclonal antibody [IgD26] recognizes IgD |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | IgD26 |
| Isotype | IgG1 |
| Target Name | IgD |
| Antigen Species | Human |
| Immunogen | IgD purified from human myeloma serum |
| Conjugation | Un-conjugated |
Application Instructions
| Application Note | WB: 1/100 - 1/1000 IP: 1-2 μl/mg of lysate IF: 1/50-1/500 IHC: 1/50-1/500 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS, < 0.1% Sodium azide and 0.1% Gelatin |
| Preservative | < 0.1% Sodium azide |
| Stabilizer | 0.1% Gelatin |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IGHD |
|---|---|
| Gene Full Name | immunoglobulin heavy constant delta |
| Function | IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD. [UniProt] |
| Research Area | Developmental Biology antibody; Immune System antibody |
