ARG45578
anti-IRBIT antibody
anti-IRBIT antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IRBIT |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IRBIT |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human IRBIT. |
| Conjugation | Un-conjugated |
| Alternate Names | AHCYL1; Adenosylhomocysteinase Like 1; XPVKONA; IRBIT; PPP1R78; Inositol 1,4,5-Trisphosphate Receptor-Binding Protein; S-Adenosylhomocysteine Hydrolase-Like Protein 1; Protein Phosphatase 1, Regulatory Subunit 78; IP(3)Rs Binding Protein Released With IP(3); S-Adenosyl-L-Homocysteine Hydrolase 2; Putative Adenosylhomocysteinase 2; DC-Expressed AHCY-Like Molecule; AdoHcyase 2; DCAL; Dendritic Cell Expressed AHCY-Like Protein; Epididymis Secretory Sperm Binding Protein; S-Adenosyl Homocysteine Hydrolase Homolog; S-Adenosylhomocysteine Hydrolase-Like 1; Adenosylhomocysteinase-Like 1; Adenosylhomocysteinase 2; EC 3.3.1.1; PRO0233 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 61 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | AHCYL1 |
| Gene Full Name | Adenosylhomocysteinase Like 1 |
| Background | The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
| Function | Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria. [UniProt] |
| Cellular Localization | Cell membrane; Cytoplasm; Endoplasmic reticulum; Membrane; Microsome. [UniProt] |
| Calculated MW | 59 kDa |
| PTM | Acetylation; Phosphoprotein. [UniProt] |
Images (8) Click the Picture to Zoom In
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ARG45578 anti-IRBIT antibody IHC-P image
Immunohistochemistry: Human bladder adenosquamous carcinoma stained with ARG45578 anti-IRBIT antibody at 2 μg/ml dilution.
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ARG45578 anti-IRBIT antibody ICC/IF image
Immunofluorescence: A431 stained with ARG45578 anti-IRBIT antibody at 5 μg/ml dilution.
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ARG45578 anti-IRBIT antibody WB image
Western blot: Hela stained with ARG45578 anti-IRBIT antibody at 0.5 μg/ml dilution.
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ARG45578 anti-IRBIT antibody WB image
Western blot: Rat pancreas stained with ARG45578 anti-IRBIT antibody at 0.5 μg/ml dilution.
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ARG45578 anti-IRBIT antibody FACS image
Flow Cytometry: CACO-2 stained with ARG45578 anti-IRBIT antibody at 1 µg/10^6 cells dilution.
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ARG45578 anti-IRBIT antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG45578 anti-IRBIT antibody at 2 μg/ml dilution.
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ARG45578 anti-IRBIT antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG45578 anti-IRBIT antibody at 2 μg/ml dilution.
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ARG45578 anti-IRBIT antibody WB image
Western blot: Mouse pancreas stained with ARG45578 anti-IRBIT antibody at 0.5 μg/ml dilution.
