ARG67038
anti-INSM 1 antibody [SQab30324]
anti-INSM 1 antibody [SQab30324] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant rabbit Monoclonal antibody [SQab30324] recognizes INSM 1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30324 |
| Isotype | IgG |
| Target Name | INSM 1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human INSM 1. |
| Conjugation | Un-conjugated |
| Protein Full Name | Insulinoma-associated protein 1 |
| Alternate Names | INSM1, INSM Transcriptional Repressor 1, IA1, IA-1, Insulinoma-Associated Protein 1, Zinc Finger Protein IA-1, Insulinoma-Associated 1, Insulinoma Associated 1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Human small cell neuroendocrine carcinoma |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05%BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | INSM1 |
| Gene Full Name | INSM Transcriptional Repressor 1 |
| Background | Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008] |
| Function | Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4'. [Uniprot] |
| Cellular Localization | Nucleus |
| Calculated MW | 53 kDa |
Images (1) Click the Picture to Zoom In
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ARG67038 anti-INSM-1 antibody [SQab30324] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded small cell neuroendocrine carcinoma stained with ARG67047 anti-Survivin antibody [SQab30320].
