ARG23318
anti-IL6R alpha antibody [B-R6] (low endotoxin)
anti-IL6R alpha antibody [B-R6] (low endotoxin) for ELISA,Flow cytometry,Functional study,IHC-Frozen sections,Immunoprecipitation and Human
Overview
| Product Description | Azide free and low endotoxin Mouse Monoclonal antibody [B-R6] recognizes IL6R alpha |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, FACS, FuncSt, IHC-Fr, IP |
| Specificity | This antibody recognizes the Interleukin-6 Ra subunit, IL-6 Ra, IL-6 R, a 80 kDa protein. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | B-R6 |
| Isotype | IgG1 |
| Target Name | IL6R alpha |
| Antigen Species | Human |
| Immunogen | IL6R alpha transfected CHO cell line |
| Conjugation | Un-conjugated |
| Alternate Names | IL-6R-alpha; CD126; IL6RA; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL6Q; CD antigen CD126; IL-6R 1; IL-6RA; gp80; IL6RQ; Interleukin-6 receptor subunit alpha; IL-6R-1; Membrane glycoprotein 80 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | Sterile-filtered through 0.22 µm and treated to remove endotoxins. |
| Buffer | PBS |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P08887 Human Interleukin-6 receptor subunit alpha |
|---|---|
| Gene Symbol | IL6R |
| Gene Full Name | interleukin 6 receptor |
| Background | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] |
| Function | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. [UniProt] |
| Calculated MW | 52 kDa |
| PTM | A short soluble form may also be released from the membrane by proteolysis. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG23318 anti-IL6R alpha antibody [B-R6] (low endotoxin) FACS image
Flow Cytometry: U266 cell line stained with ARG23318 anti-IL6R alpha antibody [B-R6] (low endotoxin).
