ARG66703
anti-IL6R alpha antibody
anti-IL6R alpha antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IL6R alpha |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IL6R alpha |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the internal region of Human IL6R alpha. |
| Conjugation | Un-conjugated |
| Alternate Names | IL-6R-alpha; CD126; IL6RA; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL6Q; CD antigen CD126; IL-6R 1; IL-6RA; gp80; IL6RQ; Interleukin-6 receptor subunit alpha; IL-6R-1; Membrane glycoprotein 80 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: EDTA buffer (pH 8.0) at high pressure and temperature. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P08887 Human Interleukin-6 receptor subunit alpha |
|---|---|
| Gene Symbol | IL6R |
| Gene Full Name | interleukin 6 receptor |
| Background | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] |
| Function | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. [UniProt] |
| Cellular Localization | Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. [UniProt] |
| Calculated MW | 52 kDa |
| PTM | A short soluble form may also be released from the membrane by proteolysis. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG66703 anti-IL6R alpha antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human spleen tissue. Antigen Retrieval: EDTA buffer (pH 8.0) at high pressure and temperature. The tissue section was stained with ARG66703 anti-IL6R alpha antibody at 1:200 diution, overnight at 4°C.
