ARG59748
anti-IL27RA / WSX1 antibody
anti-IL27RA / WSX1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IL27RA / WSX1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IL27RA / WSX1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide within the last 50 amino acids of Human IL27RA. |
| Conjugation | Un-conjugated |
| Alternate Names | IL27R; CRL1; Cytokine receptor-like 1; zcytor1; IL-27R subunit alpha; TCCR; IL-27R-alpha; Interleukin-27 receptor subunit alpha; ZcytoR1; Type I T-cell cytokine receptor; IL-27 receptor subunit alpha; WSX1; IL-27RA; Cytokine receptor WSX-1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Human spleen |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6UWB1 Human Interleukin-27 receptor subunit alpha |
|---|---|
| Gene Symbol | IL27RA |
| Gene Full Name | interleukin 27 receptor, alpha |
| Background | In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008] |
| Function | Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 69 kDa |
Images (3) Click the Picture to Zoom In
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ARG59748 anti-IL27RA / WSX1 antibody ICC/IF image
Immunofluorescence: Human spleen cells stained with ARG59748 anti-IL27RA / WSX1 antibody at 20 µg/ml dilution.
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ARG59748 anti-IL27RA / WSX1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human spleen stained with ARG59748 anti-IL27RA / WSX1 antibody at 5 µg/ml dilution.
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ARG59748 anti-IL27RA / WSX1 antibody WB image
Western blot: Human spleen lysate stained with ARG59748 anti-IL27RA / WSX1 antibody at 1 µg/ml dilution.
