ARG44033
anti-IL2 antibody [35C3] (APC)
anti-IL2 antibody [35C3] (APC) for Flow cytometry and Human
Overview
| Product Description | APC-conjugated Mouse Monoclonal antibody recognizes IL2. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 35C3 |
| Isotype | IgG2b kappa |
| Target Name | IL2 |
| Antigen Species | Human |
| Immunogen | Human IL2 recombinant protein. |
| Conjugation | APC |
| Protein Full Name | Interleukin-2 |
| Alternate Names | IL2; Interleukin 2; IL-2; TCGF; T Cell Growth Factor; Interleukin-2; Aldesleukin; Involved In Regulation Of T-Cell Clonal Expansion; T-Cell Growth Factor; Lymphokine |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Do not freeze. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL2 |
| Gene Full Name | Interleukin 2 |
| Background | This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020] |
| Function | Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells. |
| Cellular Localization | Secreted |
| PTM | Disulfide bond; Glycoprotein |
Images (1) Click the Picture to Zoom In
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ARG44033 anti-IL2 antibody [35C3] (APC) FACS image
Flow Cytometry: Human whole blood stained with ARG44033 anti-IL2 antibody [35C3] (APC) at 10 μl / 100 μl whole blood dilution.
