ARG21490
anti-IL17 / IL17A antibody [TC11-18H10] (low endotoxin)
anti-IL17 / IL17A antibody [TC11-18H10] (low endotoxin) for ELISA,ELISPOT,Flow cytometry,Neutralizing and Mouse
Overview
Product Description | Azide free and low endotoxin Rat Monoclonal antibody [TC11-18H10 ] recognizes IL17 / IL17A |
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Tested Reactivity | Ms |
Tested Application | ELISA, ELISPOT, FACS, Neut |
Specificity | Mouse IL-17A. |
Host | Rat |
Clonality | Monoclonal |
Clone | TC11-18H10 |
Isotype | IgG1, kappa |
Target Name | IL17 / IL17A |
Antigen Species | Mouse |
Immunogen | E. coli-expressed mouse IL-17 |
Conjugation | Un-conjugated |
Alternate Names | IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 |
Application Instructions
Application Suggestion |
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Application Note | Neutralizing: The clone has been used to neutralize/block IL17 activity and it led to suppress IL1 alpha, IL1 beta, IL6 and IFN gamma releasing in CHS mouse model. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification Note | Low endotoxin |
Buffer | PBS |
Concentration | 0.5 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | IL17A |
Gene Full Name | interleukin 17A |
Background | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
Function | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt] |
Highlight | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Rat IgG secondary antibodies; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 |
Calculated MW | 18 kDa |
PTM | Found both in glycosylated and nonglycosylated forms. |