ARG55184
anti-IL17 / IL17A antibody
anti-IL17 / IL17A antibody for ELISA,Western blot and Human,Mouse
Cancer antibody; Immune System antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IL17 / IL17A |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ELISA, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IL17 / IL17A |
| Antigen Species | Human |
| Immunogen | Synthetic peptide (16 aa) within aa. 40-90 of Human IL-17A. |
| Conjugation | Un-conjugated |
| Alternate Names | IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | THP-1 Cell Lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL17A |
| Gene Full Name | interleukin 17A |
| Background | Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
| Function | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt] |
| Highlight | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Rabbit IgG secondary antibodies; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 |
| Research Area | Cancer antibody; Immune System antibody |
| Calculated MW | 18 kDa |
| PTM | Found both in glycosylated and nonglycosylated forms. |
Images (1) Click the Picture to Zoom In
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ARG55184 anti-IL17 / IL17A antibody WB image
Western blot: THP-1 cell lysate stained with ARG55184 anti-IL17 / IL17A antibody at (A) 1 and (B) 2 ug/ml dilution.
