ARG43861
anti-IGSF8 / CD316 antibody [8A12]
anti-IGSF8 / CD316 antibody [8A12] for Flow cytometry,IHC-Frozen sections,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognize IGSF8 / CD316. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-Fr, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 8A12 |
| Isotype | IgG2a |
| Target Name | IGSF8 / CD316 |
| Antigen Species | Human |
| Immunogen | Human leukocytes |
| Conjugation | Un-conjugated |
| Alternate Names | IGSF8; Immunoglobulin Superfamily Member 8; CD81P3; EWI2; PGRL; CD316; Keratinocytes-Associated Transmembrane Protein 4; Glu-Trp-Ile EWI Motif-Containing Protein 2; Prostaglandin Regulatory-Like Protein; CD81 Partner 3; LIR-D1; EWI-2; KCT-4; Immunoglobulin Superfamily, Member 8; CD316 Antigen; IgSF8; KCT4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | Do not freeze. |
Bioinformation
| Database Links |
Swiss-port # Q969P0 Human Immunoglobulin superfamily member 8 |
|---|---|
| Gene Symbol | IGSF8 |
| Gene Full Name | Immunoglobulin Superfamily Member 8 |
| Background | This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. |
| Function | May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| Cellular Localization | Cell membrane; Membrane |
| Calculated MW | 65 kDa |
| PTM | Disulfide bond; Glycoprotein; Lipoprotein; Palmitate; Phosphoprotein |
Images (1) Click the Picture to Zoom In
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ARG43861 anti-IGSF8 / CD316 antibody [8A12] FACS image
Flow Cytometry: Human whole blood stained with ARG43861 anti-IGSF8 / CD316 antibody [8A12] at 5 μg/ml.
