ARG67068
anti-IGF2BP3 antibody [SQab30341]
anti-IGF2BP3 antibody [SQab30341] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant Rabbit Monoclonal antibody [SQab30341] recognizes IGF2BP3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30341 |
| Target Name | IGF2BP3 |
| Antigen Species | Human |
| Immunogen | Recombinant protein fragment of IGF2BP3 |
| Conjugation | Un-conjugated |
| Protein Full Name | IGF2BP3 |
| Alternate Names | IGF2BP3; Insulin Like Growth Factor 2 MRNA Binding Protein 3; IMP 3; IMP3; CT98; Insulin-Like Growth Factor 2 MRNA-Binding Protein 3; IGF-II MRNA-Binding Protein 3; IGF2 MRNA-Binding Protein 3; Cancer/Testis Antigen 98; VICKZ Family Member 3; VICKZ3; KOC1; KH Domain Containing Protein Overexpressed In Cancer; KH Domain-Containing Protein Overexpressed In Cancer; Insulin-Like Growth Factor 2 MRNA Binding Protein 3; IGF II MRNA Binding Protein 3; HKOC; KOC |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | -20°C |
| Note | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links |
Swiss-port # O00425 Human Insulin-like growth factor 2 mRNA-binding protein 3 |
|---|---|
| Gene Symbol | IGF2BP3 |
| Gene Full Name | Insulin Like Growth Factor 2 MRNA Binding Protein 3 |
| Background | The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008] |
| Function | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability . [UniProt] |
| Cellular Localization | Cytoplasm, Nucleusd. [UniProt] |
| Calculated MW | 64 kDa |
| PTM | Isopeptide bond; Phosphoprotein; Ubl conjugation. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG67068 anti-IGF2BP3 antibody [SQab30341] IHC-P image
Immunohistochemistry: Human pancreatic cancer tissue stained with ARG67068 anti-IGF2BP3 antibody [SQab30341] at 1:100 dilution.
