Overview

Product Description	Rabbit Polyclonal antibody recognizes ID1
Tested Reactivity	Hu, Ms, Rat
Tested Application	ICC/IF
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	ID1
Antigen Species	Human
Immunogen	Synthetic peptide derived from Human ID1.
Conjugation	Un-conjugated
Alternate Names	DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; Inhibitor of DNA binding 1; ID; bHLHb24; Inhibitor of differentiation 1

Application Instructions

Application Suggestion	Tested Application Dilution ICC/IF 1:50 - 1:200
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 25261 Rat ID1 GeneID: 3397 Human ID1 Swiss-port # P41134 Human DNA-binding protein inhibitor ID-1 Swiss-port # P41135 Rat DNA-binding protein inhibitor ID-1
Gene Symbol	ID1
Gene Full Name	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Background	The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). [UniProt]
Cellular Localization	Cytoplasm. Nucleus. [UniProt]
Calculated MW	16 kDa

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