ARG67049
anti-Histamine Receptor H1 antibody
anti-Histamine Receptor H1 antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Histamine Receptor H1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Specificity | Variants (NP_000852.1; NP_001091681.1; NP_001091682.1; NP_001091683.1) encode the same protein. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Histamine Receptor H1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 150-188 of Human HRH1. |
| Conjugation | Un-conjugated |
| Alternate Names | HRH1, Histamine Receptor H1, Histamine H1 Receptor, HH1R, H1R, Histamine Receptor, Subclass H1, HisH1, H1-R |
Application Instructions
| Application Suggestion |
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| Positive Control | WB: COLO205 ICC/IF: LoVo cell |
Properties
| Form | Liquid |
|---|---|
| Purification | affinity chromatography |
| Buffer | PBS, 0.02% Sodium azide, 0.5% BSA and 50% Glycerol |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA, 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HRH1 |
| Gene Full Name | Histamine Receptor H1 |
| Background | Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| Function | In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. [Uniprot] |
| Cellular Localization | Cell membrane, Membrane |
| Calculated MW | 56 kDa |
| PTM | Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation. [Uniprot] |
Images (2) Click the Picture to Zoom In
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ARG67049 anti-Histamine Receptor H1 antibody ICC/IF image
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ARG67049 anti-Histamine Receptor H1 antibody WB image
Western blot: COLO205 stained with ARG67049 anti-Histamine Receptor H1 antibody at 1:2000 dilution.
