ARG63708
anti-HSD11B1 antibody
anti-HSD11B1 antibody for Western blot and Human
Cancer antibody; Metabolism antibody; Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes HSD11B1 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Cow |
| Tested Application | WB |
| Specificity | This antibody is expected to recognise human HSD11B1 protein. Both NP_005516.1 and NP_861420.1 variants encode the same protein. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HSD11B1 |
| Antigen Species | Human |
| Immunogen | CTSYNMDRFINK |
| Conjugation | Un-conjugated |
| Alternate Names | Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-DH; Short chain dehydrogenase/reductase family 26C member 1; HSD11B; EC 1.1.1.146; 11-beta-hydroxysteroid dehydrogenase 1; HSD11L; HSD11; SDR26C1; HDL; 11-beta-HSD1; CORTRD2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P28845 Human Corticosteroid 11-beta-dehydrogenase isozyme 1 |
|---|---|
| Background | The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011] |
| Research Area | Cancer antibody; Metabolism antibody; Signaling Transduction antibody |
| Calculated MW | 32 kDa |
| PTM | Glycosylated. |
Images (1) Click the Picture to Zoom In
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ARG63708 anti-HSD11B1 antibody WB image
Western blot: Human Liver lysate (35 µg protein in RIPA buffer) stained with ARG63708 anti-HSD11B1 antibody at 0.3 µg/ml dilution.
