ARG65413
anti-HLA B7 antibody [BB7.1]
anti-HLA B7 antibody [BB7.1] for Flow cytometry and Human,Primates
Immune System antibody
Overview
| Product Description | Mouse Monoclonal antibody [BB7.1] recognizes HLA B7 |
|---|---|
| Tested Reactivity | Hu, NHuPrm |
| Tested Application | FACS |
| Specificity | The clone BB7.1 recognizes the HLA-B7 antigen. Although highly specific, it can cross-react with HLA-B42 antigen. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BB7.1 |
| Isotype | IgG1 |
| Target Name | HLA B7 |
| Immunogen | Papain solubilised HLA-A2, B7 |
| Conjugation | Un-conjugated |
| Alternate Names | SPDA1; HLAB; AS; MHC class I antigen B*7; HLA class I histocompatibility antigen, B-7 alpha chain |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from cell culture supernatant by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P01889 Human HLA class I histocompatibility antigen, B-7 alpha chain |
|---|---|
| Gene Symbol | HLA-B |
| Gene Full Name | major histocompatibility complex, class I, B |
| Background | HLA-B7 allele of human HLA class I major histocompatibility (MHC) antigen indicates higher risk of breast cancer and cervical cancer. Expression of HLA-B7 together with HLA-B27 is associated with increased susceptibility to spondyloarthropaties. Flow cytometry detection of these two alleles is being used to screen for patients, who suffer from inflammatory disorders affecting the sacroiliac and intervertebral joints, such as ankylosing spondylosis (AS). The HLA-B7 antigen (11 alleles) is expressed in 22% of healthy Caucasian individuals. |
| Function | Involved in the presentation of foreign antigens to the immune system. [UniProt] |
| Research Area | Immune System antibody |
| Calculated MW | 40 kDa |
| PTM | Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity). |
Clone References
Monoclonal antibodies for analysis of the HLA system.
