ARG58963
anti-HELLS / SMARCA6 antibody
anti-HELLS / SMARCA6 antibody for Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HELLS / SMARCA6 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HELLS / SMARCA6 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 719-838 of Human HELLS / SMARCA6 (NP_060533.2). |
| Conjugation | Un-conjugated |
| Alternate Names | SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6; PASG; Nbla10143; EC 3.6.4.-; LSH; Lymphoid-specific helicase; Proliferation-associated SNF2-like protein; SMARCA6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | MCF7 | ||||||
| Observed Size | 120 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HELLS |
| Gene Full Name | helicase, lymphoid-specific |
| Background | This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014] |
| Function | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 97 kDa |
Images (2) Click the Picture to Zoom In
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ARG58963 anti-HELLS / SMARCA6 antibody WB image
Western blot: 25 µg of MCF7 cell lysate stained with ARG58963 anti-HELLS / SMARCA6 antibody at 1:1000 dilution.
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ARG58963 anti-HELLS / SMARCA6 antibody IP image
Immunoprecipitation: 200 µg extracts of 293T cells were immunoprecipitated and stained with ARG58963 anti-HELLS / SMARCA6 antibody at 1:1000 dilution.
