ARG41770
anti-HDAC11 antibody
anti-HDAC11 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HDAC11 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HDAC11 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 47-81 of Human HDAC11. (NFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLN) |
| Conjugation | Un-conjugated |
| Alternate Names | HD11; EC 3.5.1.98; Histone deacetylase 11 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | ~ 39 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HDAC11 |
| Gene Full Name | histone deacetylase 11 |
| Background | This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009] |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. [UniProt] |
| Cellular Localization | Nucleus. Note=Predominantly nuclear. [UniProt] |
| Calculated MW | 39 kDa |
Images (4) Click the Picture to Zoom In
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ARG41770 anti-HDAC11 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain tissue stained with ARG41770 anti-HDAC11 antibody.
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ARG41770 anti-HDAC11 antibody WB image
Western blot: 50 µg of Rat skeletal muscle, 50 µg of Rat kidney, 50 µg of Rat cardiac muscle, 40 µg of NRK, 40 µg of 293T, 40 µg of HeLa and 40 µg of MCF7 whole cell lysates stained with ARG41770 anti-HDAC11 antibody at 0.5 µg/ml dilution.
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ARG41770 anti-HDAC11 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG41770 anti-HDAC11 antibody.
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ARG41770 anti-HDAC11 antibody WB image
Western blot: 50 µg of samples under reducing conditions. Rat brain and Mouse brain lysates stained with ARG41770 anti-HDAC11 antibody at 0.5 µg/ml dilution, overnight at 4°C.
