ARG43825
anti-GSK3 beta phospho (Ser9) antibody
anti-GSK3 beta phospho (Ser9) antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GSK3 beta phospho (Ser9) |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Specificity | Human,Mouse,Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GSK3B |
| Antigen Species | Human |
| Immunogen | Synthetic phosphopeptide around Ser9 of human GSK3 beta |
| Conjugation | Un-conjugated |
| Protein Full Name | Glycogen synthase kinase-3 beta |
| Alternate Names | GSK3B; Glycogen Synthase Kinase 3 Beta; Serine/Threonine-Protein Kinase GSK3B; Glycogen Synthase Kinase-3 Beta; EC 2.7.11.26; GSK-3 Beta; EC 2.7.11.1; EC 2.7.11 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 47 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | Tris-Glycine, 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GSK3B |
| Gene Full Name | Glycogen Synthase Kinase 3 Beta |
| Background | The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017] |
| Function | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. [UniProt] |
| Cellular Localization | Cell membrane, Cytoplasm, Membrane, Nucleus. [UniProt] |
| Calculated MW | 47 kDa |
| PTM | ADP-ribosylation, Phosphoprotein. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG43825 anti-GSK3 beta phospho (Ser9) antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human colon stained with ARG43825 anti-GSK3 beta phospho (Ser9) antibody at 1:50 dilution.
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ARG43825 anti-GSK3 beta phospho (Ser9) antibody ICC/IF image
Immunofluorescence: Hela cells stained with ARG43821 ARG43825 anti-GSK3 beta phospho (Ser9) antibody at 1:50 dilution.
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ARG43825 anti-GSK3 beta phospho (Ser9) antibody WB image
mmunofluorescence: K562, C6, 3T3 and HeLa cells stained with ARG43825 anti-GSK3 beta phospho (Ser9) antibody at 1:500 dilution.
